With complex relationships tested by romance, family, careers, addiction, faith, and force majeure, various residents from one of Washington, D.C.'s most storied neighborhoods, the historic east-of-the-river Anacostia, struggle to thrive, some at times even survive. Though the odds are overwhelming for many who call the "forgotten part of D.C.," home, the characters of Anacostia remain hopeful, drawing strength from their complicated, yet resilient friendships.