Nagisa Kasumi (the granddaughter of Nagisa Kanou, the heroine of "Fight! Iczer One") has a job as a delivery girl and makes her deliveries with a girl named Kawai on a base in the Moon. The two encounter a new race of alien villains, but are saved by Iczer-3! While Iczer-1 recovers from her long battle against Big Gold's legacy and self-proclaimed successor, Neos Gold, Sister Grey sends young Iczer-3 to Earth, and the child turns out to be the best hope against the new threat.