Loosely based on the real story of Camorra boss Raffaele Cutolo, nicknamed "O' Professore" (The Professor). His criminal career begins in prison, where he's able to build, step by step, a ruthless drug empire. He then instigates a Mafia war, destroying all the old Camorra bosses and becoming the new "boss of all bosses". With his sister Rosaria's help, he manages to escape from prison and goes to New York, where he forges an alliance with the Italian-American Mafia. Now at the peak of his power, Italian authorities are powerless to stop him...